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  J10508    
Trifluridine
, 99% (HPLC), powder
 
Trifluorothymidine
2'-Deoxy-5-trifluoromethyluridine
Trifluorothymine deoxyriboside
more..




IDENTITY
CAS Number:70-00-8
MDL Number:MFCD00006534
MF:C10H11F3N2O5
MW:296.20
EINECS:200-722-8
BRN:568095
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:186-193°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 59mg/mL; H2O: 59mg/mL; EtOH: 59mg/mL
Application(s):Thymidylate synthase
Form:Free Base

REVIEW

 An anti-herpesvirus antiviral drug, used primarily on the eye. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the -CF3 group added to the uracil component blocks base pairing.

REFERENCES
[1]Srivastav NC, Mak M, Agrawal B, Tyrrell DL, Kumar R (2010). Antiviral activity of 2,3'-anhydro and related pyrimidine nucleosides against hepatitis B virus. Bioorg Med Chem Lett. 20(22):6790-3. PMID 20863701.
[2] Suzuki N, Emura T, Fukushima M (2011). Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. Int J Oncol. 39(1):263-70. PMID 21491084.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H341; H351; H361

Precautionary Statements
P201; P202; P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P308+P313; P322; P330; P363; P405; P501


Current as of December 23, 2024


Download SDS Request COA

All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.



CATEGORIES

 APIs and Bioactives > Antivirals
 Nucleobases > Nucleosides
 Nucleobases > Nucleosides


PubChem
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