REVIEW Sodium gualenat is a water-soluble derivative of azulene, a natural product which is an antiinflammatory component of chamomile of the family of Asteraceae. Sodium gualenate was originally studied as an antiulcer agent, but it is also clinically used as a therapeutic agent in the treatment of inflammation of the mouth and throat, for example, pharyngitis as well as other inflammatory diseases such as tonsillitis, stomatitis and conjunctivitis.
REFERENCES
[1]
Nakamichi K, Nakano T, Yasuura H, Izumi S, Kawashima Y (2003). Stabilization of sodium guaiazulene sulfonate in granules for tableting prepared using a twin-screw extruder. Eur J Pharm Biopharm. 56(3):347-54. PMID 14602176.
[2]
Ogata J, Minami K, Horishita T, Shiraishi M, Okamoto T, Terada T, Sata T (2005). Gargling with sodium azulene sulfonate reduces the postoperative sore throat after intubation of the trachea. Anesth Analg. 101(1):290-3, table of contents. PMID 15976248.
[3]
Thiemer, K.; Stadler, R.; Isaac, O; Biochemical studies on chamomile constituents. 1. Antipeptic activity of chamomile extract and sodium 1,4-dimethyl-7-isopropylazulenesulfonate. Arzneimittel-Forschung (1972), 22(6), 1086-7.
[4]
Yanagisawa, Takashi; Kosakai, Kazuhiro; Tomiyama, Tsuyoshi; Yasunami, Masafumi; Takase, Kahei; Studies on antiulcer agents. II. Synthesis and antiulcer activities of 6-isopropylazulene-1-sodium sulfonate derivatives Chemical & Pharmaceutical Bulletin (1990), 38(12), 3355-8.
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