REVIEW Pamidronate sodium pentahydrate is a nitrogen-containing bisphosphonate used to prevent bone loss and treat osteoporosis. It is also used to strengthen bone in Paget's disease, to prevent bone loss due to steroid use, and in certain cancers with high propensity to the bone, such as multiple myeloma. Due to its ability to sequester calcium in bone, it is also used to treat high calcium levels.
REFERENCES
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Ham, Won Hun; Jung, Young Hun; Oh, Chang Young; Lee, Kee Young; Kim, Yong Hyun Procedure for production of 3-amino-1-hydroxypropane-1,1-diphosphonic acid Ger. Offen. (1998), DE 19737923 A1 19980305.
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Patel, Vijaykumar Muljibhai; Chitturi, Trinadha Rao; Thennati, Rajamannar A process for preparation of bisphosphonic acid compounds PCT Int. Appl. (2005), WO 2005044831 A2 20050519.
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Guenin, Erwann; Monteil, Maelle; Bouchemal, Nadia; Prange, Thierry; Lecouvey, Marc Syntheses of phosphonic esters of alendronate, pamidronate and neridronate European Journal of Organic Chemistry (2007), (20), 3380-3391, S3380/1-S3380/55.
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Fitton, Andrew; McTavish, Donna Pamidronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease Drugs (1991), 41(2), 289-318.
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