Anti-Inflammatory Agent; Antineoplastic Agent; Inhibits TGF-beta stimulated collagen production
Form:
Free Base
REVIEW Pirfenidone is an orally active synthetic antifibrotic agent and an immunosuppressant that used for the treatment of idiopathic pulmonary fibrosis. It inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tumor cell proliferation. This agent also inhibits DNA synthesis and the production of mRNA for collagen types I and III, resulting in a reduction in radiation-induced fibrosis. used for the treatment of idiopathic pulmonary fibrosis.
REFERENCES
[1]
Lee B S; Margolin S B; Nowak R A. Pirfenidone: a novel pharmacological agent that inhibits leiomyoma cell proliferation and collagen production. The Journal of Clinical Endocrinology and Metabolism. (1998) 83(1): 219-23.
[2]
Dosanjh Amrita. Pirfenidone: anti-fibrotic agent with a potential therapeutic role in the management of transplantation patients. European Journal of Pharmacology. (2006) 536(3): 219-22.
[3]
Antoniu, Sabina A. Pirfenidone for the treatment of idiopathic pulmonary fibrosis. Expert Opinion on Investigational Drugs. (2006) 15(7): 823-828.
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