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BIOLOGICAL INFO
Solubility:
DMSO: 22mg/mL; H2O: <1mg/mL; EtOH: 27mg/mL
Application(s):
Opioid-receptor agonist
Form:
HCl salt
REVIEW Loperamide is a synthetic anti-diarrheal indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also it is used for reducing the volume of discharge from ileostomies. Loperamide is an opioid receptor agonist and acts on the mu opioid receptors in the myenteric plexus large intestines; it does not affect the central nervous system like other opioids.
REFERENCES
[1]
Ruppin H. Review: loperamide-a potent antidiarrhoeal drug with actions along the alimentary tract. Aliment Pharmacol Ther. (1987) Jun;1(3): 179-90.
[2]
Van Rompay, Jos; Carter, James E. Loperamide hydrochloride. Analytical Profiles of Drug Substances. (1990) 19: 341-65.
[3]
Huighebaert S, Awouters F, Tytgat GN. Racecadotril versus loperamide: antidiarrheal research revisited. Dig Dis Sci. (2003) Feb;48(2): 239-50.
[4]
Janssen, Paul A. J.; Niemegeers, Carlos J. E. J.; Stokbroekx, Raymond Antoine; Vandenberk, Jan 2,2-Diaryl-4-(4-aryl-4-hydroxypiperidino)butyramides Fr. Demande (1972), FR 2100711 A1 19720428
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