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  J10417    AKSci Reference Standard
Clinofibrate, >99% (HPLC)
 
2-(4-{1-[4-(1-carboxy-1-methylpropoxy)phenyl]cyclohexyl}phenoxy)-2-methylbutanoic acid
IDENTITY
CAS Number:30299-08-2
MDL Number:MFCD00865769
MF:C28H36O6
MW:468.58
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:143-146°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR)

REVIEW
 Clinofibrate is a fibrate drug that inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with an IC50 of 0.47 mM. It is a plasma lipid-lowering agent used for controlling high cholesterol and tricylglyceride levels in the blood. It modifies lipid metabolism, diminishing the steroid-induced accumulation of lipids within osteocytes. It also can effectively reduce the plasma fibrinogen level.

REFERENCES
[1]Suzuki, Yoshio; Minai, Masayoshi; Hamma, Noritaka; Murayama, Eiichi; Aono, Shunji Bisphenoxy acid derivatives Jpn. Kokai Tokkyo Koho (1973), JP 48000552 A 19730106.
[2] Nakamura, Yasushi; Hamma, Noritaka; Agatsuma, Kunio; Murayama, Eiichi [Cyclohexylidenebis(4,1-phenyleneoxy)]bis[alkanoic acids] Jpn. Tokkyo Koho (1972), JP 47048378 B4 19721206.
[3] Yoshitake, Akira; Makari, Yoshiaki; Hamma, Noritaka; Suzuki, Yoshio Aryloxy fatty acid esters Jpn. Kokai Tokkyo Koho (1973), JP 48054047 A 19730730.
[4] Toki K, Nakamura Y, Agatsuma K, Nakatani H, Aono S.Hypolipidemic action of a new aryloxy compound (S-8527) in rats.Atherosclerosis. 1973 Jul-Aug;18(1):101-8.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of January 20, 2025

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Hypercholesterolemia, Fibrates


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