REVIEW Carticaine (also called articaine) is a dental local anesthetic. It is the most widely used local anesthetic in a number of European countries and is available in many countries around the world Carticaine was first synthesized by Rusching in 1969, and brought to the market in Germany by Hoechst AG, under the brand name Ultracain. This drug was originally referred to as ''carticaine'' until 1984. In 1983 it was brought into the North American market, to Canada, under the name Ultracaine for dental use, manufactured in Germany and distributed by Hoechst-Marion-Roussel. This brand is currently manufactured in Germany by Sanofi-Aventis and distributed in North America by Hansamed Limited (since 1999). After Ultracaine's patent protection expired, new generic versions arrived to the Canadian market: (in order of appearance) Septanest (Septodont), Astracaine, (originally by AstraZeneca and now a Dentsply product), and Zorcaine (Carestream Health/Kodak). It was approved by the FDA in April 2000, and became available in the United States of America two months later under the brand name Septocaine, an anesthetic/vasoconstrictor combination with Epinephrine 1:100,000 (trade name Septodont). Zorcaine became available there a few years later, also. Articadent (Dentsply) became available in the United States in October 2010. The three brands currently available in the United States are all manufactured for these companies by Novocol Pharmaceuticals Inc. (Canada). Ubistesin and Ubistesin Forte are also widely used in the United States and Europe. Carticaine is used for pain control. Like other local anesthetic drugs, articaine causes a transient and completely reversible state of anesthesia (loss of sensation) during dental procedures, where articaine is used both for infiltration and block injections, with the block technique yielding the greatest duration of anesthesia.
REFERENCES
[1]
Ruschig, Heinrich; Schorr, Manfred; Muschaweck, Roman; Rippel, Robert S. African (1969), ZA 6804265 19690115.
[2]
Winther, J. E.; Nathalang, B. Effectivity of a new local analgesic Hoe 40045Scandinavian. Journal of Dental Research (1972), 80(4), 272-8.
[3]
Muschaweck, R.; Rippel, R. New local anesthetic (Carticaine) from the thiopene series. Praktische Anaesthesie (1974), 9(3), 135-46.
[4]
Leith R, Lynch K, O'Connell AC Articaine use in children: a review. Eur Arch Paediatr Dent. 2012 Dec;13(6):293-6.
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