REVIEW Decitabine is a cytidine antimetabolite nucleoside analogue with potential antineoplastic activity. The incorporation of Decitabine into DNA or RNA inhibits methyltransferase thereby causing demethylation in that sequence. This adversely affects the way that cell regulatory proteins are able to bind to the DNA/RNA substrate. It is used for the treatment of patients with myelodysplastic syndromes (MDS).
REFERENCES
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Marks, Peter W. Decitabine for acute myeloid leukemia. Expert Review of Anticancer Therapy. (2012) 12(3): 299-305.
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Santos, Fabio P. S.; Kantarjian, Hagop; Garcia-Manero, Guillermo; Issa, Jean-Pierre; Ravandi, Farhad. Decitabine in the treatment of myelodysplastic syndromes. Expert Review of Anticancer Therapy. (2010) 10(1): 9-22.
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van Camp, Jennifer A. Decitabine (Dacogen): A DNA methyltransferase inhibitor for cancer Edited by Li, Jie Jack; Johnson, Douglas S. Modern Drug Synthesis (2010): 47-55.
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Pliml, J.; Sorm, F.Synthesis of 2-deoxy-D-ribofuranosyl-5-azacytosine Collection of Czechoslovak Chemical Communications (1964), 29, 2576-8.
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