REVIEW Vincristine Sulfate is a kind of microtubule function inhibitor with IC50 of 10.4±1.1, 28.1±3.4, 22.4±2.1 µM for HL-60, Bel7402, HO-8910, respectively. It is the sulfate salt of a natural alkaloid isolated from the plant Vinca rosea Linn with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. The IC50 and IC90 of vincristine for the 4 vaccine-associated feline sarcoma (VAFS) cell lines were between 0.005 to 0.039 µg/ml and 0.045 to 1.027 µg/ml, respectively .This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism.
REFERENCES
[1]
Qweider, M.; Gilsbach, J. M.; Rohde, V. (2007). Inadvertent Intrathecal Vincristine Administration: A Neurosurgical Emergency. Case Report. Journal of Neurosurgery: Spine 6 (3): 280-283. PMID 17355029.
[2]
Graf, W. D.; Chance, P. F.; Lensch, M. W.; Eng, L. J.; Lipe, H. P.; Bird, T. D. (1996). Severe Vincristine Neuropathy in Charcot-Marie-Tooth Disease Type 1A. Cancer 77 (7): 1356-1362. PMID 8608515.
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