REVIEW Cromolyn works because it prevents the release of mediators that would normally attract inflammatory cells and because it stabilizes the inflammatory cells.Nedocromil is another mast cell stabilizer that also works in controlling asthma. The underlying mechanism of action is not fully understood; for while cromoglicate stabilizes mast cells, this mechanism is probably not why it works in asthma. Pharmaceutical companies have produced 20 related compounds that are equally or more potent at stabilising mast cells and none of them have shown any anti-asthmatic effect. It is more likely that these work by inhibiting the response of sensory C fibers to the irritant capsaicin, inhibiting local axon reflexes involved in asthma, and may inhibit the release of preformed T cell cytokines and mediators involved in asthma.
REFERENCES
[1]
Fanta CH (March 2009). Asthma. New England Journal of Medicine 360 (10): 1002-14. doi:10.1056/NEJMra0804579. PMID 19264689.
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Schwartz HJ, Blumenthal M, Brady R, et al. (April 1996). A comparative study of the clinical efficacy of nedocromil sodium and placebo. How does cromolyn sodium compare as an active control treatment?. Chest 109 (4): 945-52. doi:10.1378/chest.109.4.945. PMID 8635375.
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