Almost insoluble in water and diethyl ether; Highly soluble in ethanol, acetone, chloroform, and benzene
Application(s):
Transcription inhibitor
REVIEW 8-Hydroxyquinoline is an antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It has also been used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used as topical anti-infective agents and oral antiamebics. The metal chelation complexes as well as the heterocycle itself exhibit antiseptic, disinfectant, and pesticide properties, functioning as a transcription inhibitor. Its solution in alcohol is used in liquid bandages. It once was of interest as an anti-cancer drug.
REFERENCES
[1]
Prachayasittikul V, Prachayasittikul S, Ruchirawat S, Prachayasittikul V. 8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications. Drug Des Devel Ther. 2013 Oct 4;7:1157-1178.
[2]
Neldner KH.The halogenated 8-hydroxyquinolines. Int J Dermatol. 1977 May;16(4):267-73.
[3]
Pierre JL, Baret P, Serratrice G. Hydroxyquinolines as iron chelators. Curr Med Chem. 2003 Jun;10(12):1077-84.
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