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		J40158    AKSci Reference Standard
				
      Trilostane      , 99% (HPLC), powder      		
	
    
      
    
      
      
      
        
		
      
            
      
			     
              
			  
      
                    
      
                      
					  
      (4alpha,5alpha,17beta-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
       Vetoryl


       

      		
				
      
                
      
                  

				  
      
					
      
					
      
						
      IDENTITY
      

  
      CAS Number:13647-35-3
      MDL Number:MFCD00199295
      MF:C20H27NO3
      MW:329.43
      EINECS:237-133-0
      					
      		
					
      
		  				
      SPECIFICATIONS & PROPERTIES
      
  
      Min. Purity Spec:99% (HPLC), powder
      Physical Form (at 20°C):Solid
      Melting Point:257-270°C
      Long-Term Storage:Store long-term at 2-8°C
                        
      

              
              
              
              
                  
      
		  				
      DOT/IATA TRANSPORT INFORMATION
      
  
      Not hazardous material
                        
      
				  
      
					      		
				  
      
				  
				  
              
                   
              

      


      BIOLOGICAL INFO
      Solubility:DMSO: >=17mg/mL;H 2O: <1mg/mL; EtOH: <1mg/mL
      Application(s):Inhibitor of 3 beta-hydroxysteroid dehydrogenase (3-beta-HSD)
      Form:Free Base
      


      REVIEW
       Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
      

      REFERENCES
      
  
      [1]Komanicky P, Spark RF, Melby JC: Treatment of Cushing's syndrome with trilostane (WIN 24,540), an inhibitor of adrenal steroid biosynthesis. J Clin Endocrinol Metab. 1978 Nov;47(5):1042-51.
      [2] Ouschan C, Lepschy M, Zeugswetter F, M?stl E (2012). The influence of trilostane on steroid hormone metabolism in canine adrenal glands and corpora lutea-an in vitro study. Vet Res Commun. 36(1):35-40. PMID 22113849.
      		

      
GLOBALLY HARMONIZED SYSTEM (GHS)

      Pictograms
        

      Signal Word
      Warning

      Hazard Statements
      H315; H319; H361

      Precautionary Statements
      P201; P202; P264; P280; P302+P352; P305+P351+P338; P308+P313; P321; P332+P313; P337+P313; P362; P405; P501

      
		      		
              
      
          
      
        
      
            
      
              
			  
			  
      
                    		
            
      
          
      

    
      
	

      
	    Current as of January 11, 2025 
       
      AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.	
      


      
Download SDS Request COA 



      
All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.

      All batches backed with full quality assurance.
      

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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons. 

      

      
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

      

      
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

      

      
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.      


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       WARNING: Attention California residents: This product can expose you to chemicals including Trilostane, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.
      

      



      


      CATEGORIES
       APIs and Bioactives > Veterinary


      
	PubChem
      			

              		

    
      		
  
      

      

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