REVIEW Vinorelbine tartrate, the orally available ditartrate salt of vinorelbine, a semisynthetic vinca alkaloid ) with antineoplastic activity derived from the leaves of the periwinkle plant (Vinca rosea. Vinorelbine binds to tubulin, inhibiting its polymerization into microtubules and spindle formation, resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with vinorelbine's antitumor activity, whereas inhibition of axonal microtubules seems to correlate with its neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account for its decreased neurotoxicity. This agent is also a radiation-sensitizing agent.
REFERENCES
[1]
Liu, Suyun; Que, Riming Synthesis of vinorelbine tartrate Zhongguo Yiyao Gongye Zazhi (2010), 41(9), 645-648.
[2]
Moyano, Nora; Iturraspe, Jose; Nunez, Jose Lucio Process for the production of 5'-noranhydrovinblastine ditartrate from plants of genus Catharanthus Eur. Pat. Appl. (2001), EP 1118616 A1 20010725.
[3]
Xu YC, Wang HX, Tang L, Ma Y, Zhang FC.A systematic review of vinorelbine for the treatment of breast cancer. Breast J. 2013 Mar-Apr;19(2):180-8.
[4]
Marty M, Fumoleau P, Adenis A, Rousseau Y, Merrouche Y, Robinet G, Senac I, Puozzo C: Oral vinorelbine pharmacokinetics and absolute bioavailability study in patients with solid tumors. Ann Oncol. 2001 Nov;12(11):1643-9.
All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
??
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
Add to Favorites 
Delete from Favorites 
