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BIOLOGICAL INFO
Solubility:
H2O; 1 M HCl: 50 mg/mL
Application(s):
Inhibitors of serotonin and norepinephrine reuptake
Form:
HCl salt
REVIEW The mechanism of action of doxepin is not completely understood. It is thought that like amitriptyline, doxepin enhances the actions of norepinephrine and serotonin by blocking their reuptake at the neuronal membrane. However, doxepin weakly inhibits the reuptake of dopamine. Doxepin may also act on histamine H1-receptors, resulting in sedative effects, and β-adrenergic receptors. It is also an antagonist of 5-hydroxytryptamine (serotonin) receptors, alpha-1 adrenergic receptor, and muscarinic cholinergic receptors.
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All batches backed with full quality assurance.
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