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Oleandomycin

oleandomycin Struktur
3922-90-5
CAS-Nr.
3922-90-5
Bezeichnung:
Oleandomycin
Englisch Name:
oleandomycin
Synonyma:
C01946;PA 775;PA-105;Romicil;Amimycin;Landomycin;oleandomycin;OleandoMycin A;Antibiotic PA-105;AMiMycin, MatroMycin, PA 105
CBNumber:
CB5928730
Summenformel:
C35H61NO12
Molgewicht:
687.86
MOL-Datei:
3922-90-5.mol

Oleandomycin Eigenschaften

Schmelzpunkt:
110 °C (decomp)
Siedepunkt:
802.6±65.0 °C(Predicted)
Dichte
1.21±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
pka
pKa 8.84(H2O,t =25,I=0.167) (Uncertain)
Aggregatzustand
Solid
Farbe
White to Off-White

Sicherheit

Giftige Stoffe Daten 3922-90-5(Hazardous Substances Data)
Toxizit?t LD50 orl-rat: 6700 mg/kg AMPMAR 39,259,1978

Oleandomycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Antibiotic substance produced by Streptomyces antibioticus no. ATCC 11891. Antibacterial.

Pharmazeutische Anwendungen

A natural 14-membered-ring macrolide produced by Streptomyces antibioticus. It is stable in acid conditions. It is less active than erythromycin A in vitro, but four times more active than spiramycin . Several attempts have been made to improve its potency by chemical modification while retaining its relative acid stability.
It is incompletely absorbed, but an ester, triacetyloleandomycin, gives improved plasma levels. Following doses of 0.5 g, mean peak serum levels around 0.8 mg/L were reached by the base and 2 mg/L by the triacetyl ester. A single oral dose of 1 g of the ester produced a mean plasma oleandomycin concentration of 4 mg/L at 1 h after dosing, with an AUC of 14 mg.h/L. The apparent elimination half-life was 4.2 h. Significant quantities of mostly inactivated compound are eliminated in the bile. About 10% of the dose appears in the urine after administration of the base and about 20% after the ester.
Nausea, vomiting and diarrhea are common. Like erythromycin estolate, triacetyloleandomycin can cause liver damage. Abnormal liver function tests were found in about one-third of patients treated for 2 weeks. Hepatic dysfunction resolved when treatment was discontinued. The action of drugs eliminated via the cytochrome P450 system may be potentiated.
Its uses are similar to those of erythromycin. It is of restricted availability.

Sicherheitsprofil

A poison by intravenous route. Low toxicity by ingestion. When heated to decomposition it emits toxic vapors of NOx.

Oleandomycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Oleandomycin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 52)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-029-81138252 +86-18789408387
1057@dideu.com China 3958 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289
contact@trustwe.com China 5738 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32002 58
Zhejiang Huida Biotech Co., LTD
008613515763466 8615669048680
wendy@huidabiotech.com CHINA 87 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6391 58
Zibo Hangyu Biotechnology Development Co., Ltd
+86-0533-2185556 +8617865335152
Mandy@hangyubiotech.com China 10986 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52925 58
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32321 50
T&W GROUP 021-61551611 13296011611
contact@trustwe.com China 9895 58

3922-90-5(Oleandomycin)Verwandte Suche:


  • C01946
  • 8-(3,5-Dihydroxy-2,4-diMethylhexanoyl)-5-(4-diMethylaMinotetrahydro-3-hydroxy-6-Methylpyran-2-yloxy)-8,9-epoxy-2,4,6-triMethyl-3-(tetrahydro-5-hydroxy-4-Methoxy-6-Methylpyran-2-yloxy)nonanoic Acid μ-Lactone
  • OleandoMycin A
  • PA 775
  • AMiMycin, MatroMycin, PA 105
  • oleandomycin
  • Oleandomycin (base and/or unspecified salts)
  • Amimycin
  • Antibiotic PA-105
  • Landomycin
  • PA-105
  • Romicil
  • Oleandomycin, sum of isomers in methanol
  • 3922-90-5
  • C35H61NO12
  • C35H61NO11
  • Carbohydrates & Derivatives
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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