Zidovudine NEW
| Price | $44 | $58 | $76 |
| Package | 50mg | 100mg | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-05 |
Product Details
| Product Name: Zidovudine | CAS No.: 30516-87-1 |
| Purity: 99.91% | Supply Ability: 10g |
| Release date: 2024/11/05 |
Product Introduction
Bioactivity
| 名稱 | Zidovudine |
| 描述 | Zidovudine (ZDV) is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines. |
| 細(xì)胞實(shí)驗(yàn) | Zidovudine is prepared in DMSO (10 mM) and stored, and then diluted with appropriate medium before use[1]. Assays are performed in all cell types in the presence of titrating concentrations of ARV. 5,000 SVG, 2,500 PFA, 200,000 PBMC, or 50,000 MDM cells/well are seeded into triplicate wells of 96-well plates. Twenty-four hours later, the culture medium is removed and replaced with medium containing the ARV or DMSO (0.5% vol/vol), and equivalent TCID50 infectious units of luciferase reporter virus are added to the cells. After a 16 h incubation at 37°C, the initial viral inoculum is removed and replaced with culture medium containing the same antiretroviral drug (ARV) or DMSO (0.5% vol/vol) concentrations. At 72 h post infection, the medium is aspirated, the cells are lysed and HIV-1 infection measured using the Luciferase Assay System. Luminescence is measured using a FLUOStar Optima microplate reader. Inhibition curves and the 50% (EC50) and 90% (EC90) effective concentrations are determined by nonlinear regression analysis, using GraphPad Prism software[1]. |
| 體內(nèi)活性 | Intravitreal injection of Nucleoside Reverse Transcriptase Inhibitors (NRTIs) Lamivudine (3TC), Zidovudine (AZT), or Abacavir (ABC) significantly mitigates laser-induced choroidal neovascularization (CNV) in wild-type mice when compared to the PBS vehicle treatment. Additionally, these NRTIs lead to a notable reduction in the mean VEGF-A levels within the RPE/choroid area, which typically reach their highest concentration on day 3 post-laser injury, in treated eyes relative to control eyes in wild-type mice. This effect, however, does not extend to P2rx7 knockout (P2rx7-/-) mice[6]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 13.4 mg/mL (50 mM) DMSO : 60 mg/mL (224.52 mM), Sonication is recommended. |
| 關(guān)鍵字 | HIV | CRISPR/Cas9 | inhibit | Human immunodeficiency virus | Inhibitor | NSC602670 | Zidovudine | NSC-602670 |
| 相關(guān)產(chǎn)品 | Stavudine | Emtricitabine | Lamivudine |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 抗病毒庫 | 藥物功能重定位化合物庫 | FDA 上市藥物庫 | 抗衰老化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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