Zatosetron maleate NEW
| Price | $700 | $1800 |
| Package | 1mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-20 |
Product Details
| Product Name: Zatosetron maleate | CAS No.: 123482-23-5 |
| Purity: 99.41% | Supply Ability: 10g |
| Release date: 2024/11/20 |
Product Introduction
Bioactivity
| Name | Zatosetron maleate |
| Description | Zatosetron maleate（LY 277359 maleate） is a potent and selective serotonin 5HT3 receptor antagonist for the study of acute migraine. |
| In vivo | Acute administration of Zatosetron maleate at doses of 0.1 mg/kg (n=21) and 0.3 mg/kg (n=5) significantly reduces the activity of A10 dopamine cells in male rats, an effect not observed with doses of 0.01, 0.05, 1.0, or 10 mg/kg or with saline administration. The reduction in active A10 dopamine cells begins 60 minutes post-intraperitoneal (i.p.) administration at 0.1 mg/kg, with significant decreases observed at 60-90 minutes (0.65±0.11, P=0.03, n=5), deepening at 90-120 minutes (0.53±0.08, P=0.004, n=5), and stabilizing from 2 to 3 hours (0.50±0.05, P=0.0004, n=5). Single-unit recordings reveal that intravenous (i.v.) administration of Zatosetron maleate inhibits A10 dopamine cell activity with an ED50 of 0.12 mg/kg (n=8). Chronic administration at 0.1 mg/kg (n=16) also leads to a significant decrease in active A10 dopamine cells, with no significant effect at doses of 0.01, 1.0, or 10 mg/kg or with saline (n=4, 8, 7, and 5, respectively). |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | Zatosetron Maleate | LY 277359 Maleate | LY277359 Maleate | LY-277359 Maleate |
| Inhibitors Related | Alverine citrate | Olanzapine | Dapoxetine hydrochloride | CLOZAPINE N-OXIDE | Amitriptyline hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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