Product Name:    Yohimbine hydrochloride

Synonyms:    17-HYDROXYYOHIMBAN-16-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;17A-HYDROXYYOHIMBAN-16A-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;YOHIMBE HCL;YOHIMBINE HCL;YOHIMBINE HYDROCHLORIDE;QUERBRACHINE;17alpha)-alph;Yohimban-16-alpha-carboxylic acid, 17-alpha-hydroxy, methyl ester, monohydrochloride

CAS:    65-19-0

MF:    C21H27ClN2O3

MW:    390.9

EINECS:    200-600-4

Product Categories:    chemical reagent;pharmaceutical intermediate;Adrenoceptors;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Alkaloids;Biochemistry;Indole Alkaloids;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API;Natural Plant Extract;Adrenoceptor;ADENYL;Inhibitors;65-19-0

Yohimbine hydrochloride is an α2-adrenergic receptor antagonist and increases the firing rate of the locus coeruleus with a resultant increase in sympathetic outflow (Redmond, 1987). Oral and intravenous yohimbine causes an increase in MHPG and blood pressure in healthy human subjects (Charney et al., 1982d; Goldberg et al., 1986). Depressed patients demonstrate an increased cortisol and blood pressure response to intravenous yohimbine compared with healthy subjects, while plasma MHPG is not significantly different between the two groups of subjects (Heninger et al., 1988). The effects of acute or chronic antidepressant treatments on the neuroendocrine or behavioural responses to yohimbine in depressed patients have not been studied.