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Postion:Product Catalog >YM-46303
YM-46303
  • YM-46303

YM-46303 NEW

Price $700 $1800
Package 1mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-07

Product Details

Product Name: YM-46303 CAS No.: 171722-81-9
Purity: 100% Supply Ability: 10g
Release date: 2024/11/07

Product Introduction

Bioactivity

名稱YM-46303
描述YM-46303 is a selective and potent muscarinic receptor antagonist that exhibits high affinity for the M3 receptor.YM-46303 can be used to study bradycardia in medullary rats.
體內(nèi)活性YM-46303, when compared to oxybutynin, exhibits approximately ten times higher inhibitory activity on bladder pressure in reflexly-evoked rhythmic contraction, along with about a 5-fold greater selectivity for urinary bladder contraction over salivary secretion in rats. Evaluation of antimuscarinic effects on bradycardia and pressor responses in pithed rats, as well as on tremor in mice, reveals that YM-46303 could be valuable for treating urinary urge incontinence. It functions as a bladder-selective M3 antagonist with potent activities and fewer side effects[1]. In vivo, YM-46303 demonstrates selective inhibitory activities on bladder pressure in reflexly-evoked rhythmic contraction against oxotremorine-induced salivary secretion. Additionally, it shows potent activity in a guinea pig model of methacholine-induced bronchospasm upon intravenous administration[1].
存儲(chǔ)條件store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
關(guān)鍵字YM-46303 | YM46303 | YM 46303
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Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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