YH239-EE NEW
| Price | $60 | $96 | $198 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-04 |
Product Details
| Product Name: YH239-EE | CAS No.: 1364488-67-4 |
| Purity: 99.61% | Supply Ability: 10g |
| Release date: 2024/11/04 |
Product Introduction
Bioactivity
| 名稱 | YH239-EE |
| 描述 | YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer. |
| 細(xì)胞實(shí)驗(yàn) | Cell lines are harvested in log-phase growth and seeded following exposure to p53-MDM2 antagonists. Cell number and viability are determined by staining cells with Trypan blue 0.4% and counted with Countess slides.(Only for Reference) |
| 體外活性 | YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). [1] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 15 mg/mL (29.7 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 93 mg/mL (184.4 mM) |
| 關(guān)鍵字 | Apoptosis | E2 conjugating enzyme | Ubiquitin activating enzyme | YH239 EE | E1/E2/E3 Enzyme | Ubiquitin conjugating enzyme | YH239-EE | E1 activating enzyme | E3 ligating enzyme | inhibit | Inhibitor | YH-239-EE | YH239EE | MDM-2/p53 | Ubiquitin ligase |
| 相關(guān)產(chǎn)品 | Stavudine | 5-Fluorouracil | Acetylcysteine | Kaempferol | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin | Lidocaine hydrochloride |
| 相關(guān)庫(kù) | 細(xì)胞凋亡化合物庫(kù) | 抗肺癌化合物庫(kù) | 糖代謝化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 泛素化化合物庫(kù) | 抗癌細(xì)胞代謝庫(kù) | 抑制劑庫(kù) | 干細(xì)胞分化化合物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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