xStAx-VHLL TFA NEW
Price | $295 | $738 | $987 |
Package | 1mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-07 |
Product Details
Product Name: xStAx-VHLL TFA | Supply Ability: 10g |
Release date: 2024/11/07 |
Product Introduction
Bioactivity
名稱 | xStAx-VHLL TFA |
描述 | xStAx-VHLL TFA is a β-catenin degrader formed by coupling xStAx to VHL ligand, has anti-cancer activity, inhibits Wnt signaling, and can be used in the study of cancer. |
體外活性 | Both 10?μM MSAB and 50?μM xStAx-VHLL TFA decreased β-catenin protein to a comparable level after 24?h treatment in HEK293T, HCT116, and SW480 cells. In LoVo cells, only xStAx-VHLL TFA was able to reduce the β-catenin protein level, while MSAB had no effect. [1] |
體內(nèi)活性 | Because APCmin/+ mice can develop intestinal tumors around 10 weeks-old, the 11 weeks-old APCmin/+ mice were intraperitoneally injected with 30?mg/kg vehicle DMSO or xStAx-VHLL TFA at every other day for 14 days. The xStAx-VHLL TFA reduced tumor number compared with that of 11 weeks-old mice before treatment (day 0) or with vehicle DMSO treatment. [1] |
存儲(chǔ)條件 | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 80 mg/mL, Sonication is recommended. H2O : 80 mg/mL |
關(guān)鍵字 | xStAxVHLLTFA |
相關(guān)產(chǎn)品 | ARV-393 HCl | Gefitinib-based PROTAC 3 | ACBI1 | ARV-471 | dBET6 | dBET1 | Dbet57 | ARV-825 | NH2-PEG2-C6-Cl hydrochloride | β-NF-JQ1 | C004019 | GMB-475 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
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