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Postion:Product Catalog >xStAx-VHLL TFA
xStAx-VHLL TFA
  • xStAx-VHLL TFA

xStAx-VHLL TFA NEW

Price $295 $738 $987
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-07

Product Details

Product Name: xStAx-VHLL TFA Supply Ability: 10g
Release date: 2024/11/07

Product Introduction

Bioactivity

名稱xStAx-VHLL TFA
描述xStAx-VHLL TFA is a β-catenin degrader formed by coupling xStAx to VHL ligand, has anti-cancer activity, inhibits Wnt signaling, and can be used in the study of cancer.
體外活性Both 10?μM MSAB and 50?μM xStAx-VHLL TFA decreased β-catenin protein to a comparable level after 24?h treatment in HEK293T, HCT116, and SW480 cells. In LoVo cells, only xStAx-VHLL TFA was able to reduce the β-catenin protein level, while MSAB had no effect. [1]
體內(nèi)活性Because APCmin/+ mice can develop intestinal tumors around 10 weeks-old, the 11 weeks-old APCmin/+ mice were intraperitoneally injected with 30?mg/kg vehicle DMSO or xStAx-VHLL TFA at every other day for 14 days. The xStAx-VHLL TFA reduced tumor number compared with that of 11 weeks-old mice before treatment (day 0) or with vehicle DMSO treatment. [1]
存儲(chǔ)條件keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 80 mg/mL, Sonication is recommended.
H2O : 80 mg/mL
關(guān)鍵字xStAxVHLLTFA
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Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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