XL388 NEW
| Price | $38 | $53 | $89 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: XL388 | CAS No.: 1251156-08-7 |
| Purity: 99.53% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | XL388 |
| Description | XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases. |
| Kinase Assay | Determination of Enzyme IC50 Values: IC50 values are determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled-enzyme format, according to the manufacturer's protocol (Z'-LYTE@biochemical assay). Kinase selectivity is determined using both the Z'-LYTE@ and Adapta@ kinase assay format. |
| In vitro | In vitro, XL388 inhibited the activity of solid and hematopoietic tumor cell lines as well as the proliferation of MCF-7 cell line (IC50: 1.37 μM). xL388 inhibited mTORC1 phosphorylation of p70S6K (T389) in MCF-7 cells (IC50: 94 nM). xL388 inhibited the phosphorylation of mTORC2 by AKT (S473) (IC50 : 350 nM). |
| In vivo | In vitro, XL388 inhibited the activity of solid and hematopoietic tumor cell lines as well as the proliferation of MCF-7 cell line (IC50: 1.37 μM). xL388 inhibited mTORC1 phosphorylation of p70S6K (T389) in MCF-7 cells (IC50: 94 nM). xL388 inhibited the phosphorylation of mTORC2 by AKT (S473) (IC50 : 350 nM). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 22 mg/mL (48.3 mM) Ethanol : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | inhibit | XL388 | Mammalian target of Rapamycin | XL-388 | Inhibitor | mTOR | XL 388 |
| Inhibitors Related | Tebuconazole | 1-Ethynylnaphthalene | Diflubenzuron | Myricetin | Apigenin | Fenofibrate | 1-Aminobenzotriazole | Isoprenaline hydrochloride | Naringin | Naringenin | Tauroursodeoxycholate | Quercetin |
| Related Compound Libraries | Highly Selective Inhibitor Library | Bioactive Compound Library | Antidepressant Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library | Anti-Cancer Active Compound Library | Neuronal Differentiation Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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