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XL177A NEW

Price	$97	$197	$313
Package	1mg	5mg	10mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-18

Product Details

Product Name: XL177A	CAS No.: 2417089-74-6
Purity: 98.75%	Supply Ability: 10g
Release date: 2024/11/18

Product Introduction

Bioactivity

名稱	XL177A
描述	XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.
體外活性	XL177A irreversibly inhibits USP7 with sub-nM potency and selectivity across the human proteome.?Evaluation of the cellular effects of XL177A reveals that selective USP7 inhibition suppresses cancer cell growth predominantly through a p53-dependent mechanism:?XL177A specifically upregulates p53 transcriptional targets transcriptome-wide, hotspot mutations in TP53 but not any other genes predict response to XL177A across a panel of ~500 cancer cell lines, and TP53 knockout rescues XL177A-mediated growth suppression of TP53 wild-type (WT) cells.?Together, these findings suggest TP53 mutational status as a biomarker for response to USP7 inhibition.?We find that Ewing sarcoma and malignant rhabdoid tumor (MRT), two pediatric cancers that are sensitive to other p53-dependent cytotoxic drugs, also display increased sensitivity to XL177A.
存儲條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 55 mg/ml (63.84 mM)
關(guān)鍵字	MCF7 \| Deubiquitinase \| inhibit \| Inhibitor \| cancer \| XL-177A \| DUBs \| p53 \| XL177A \| USP7
相關(guān)產(chǎn)品	P22074 \| BAY 11-7082 \| USP15-IN-1 \| N-Ethylmaleimide \| DUB-IN-1 \| SJB3-019A \| USP30 inhibitor 11 \| Vialinin A \| GRL0617 \| Spautin-1 \| 6-Thioguanine \| USP8-IN-3
相關(guān)庫	DNA 損傷和修復(fù)分子庫 \| 經(jīng)典已知活性庫 \| 泛素化化合物庫 \| HIF-1化合物庫 \| 抑制劑庫 \| 抗衰老化合物庫 \| 已知活性化合物庫 \| 細胞周期化合物庫 \| 抗癌化合物庫 \| 抗癌活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.