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Postion:Product Catalog >WR99210 hydrochloride(47326-86-3 free base)
WR99210 hydrochloride(47326-86-3 free base)
  • WR99210 hydrochloride(47326-86-3 free base)

WR99210 hydrochloride(47326-86-3 free base) NEW

Price $85 $173 $248
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-07

Product Details

Product Name: WR99210 hydrochloride(47326-86-3 free base) CAS No.: 30711-93-4
Purity: 99.19% Supply Ability: 10g
Release date: 2024/11/07

Product Introduction

Bioactivity

名稱WR99210 hydrochloride(47326-86-3 free base)
描述WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target. It has subnanomolar potency for the wild type, double mutant and quadruple mutant dihydrofolate reductases.
體外活性When tested in vitro against drug-resistant clones of P. falciparum, PS-15 was more active than proguanil, and the putative metabolite, WR99210, was more active than the proguanil metabolite cycloguanil[1].
體內(nèi)活性QR992210 is more active as well as less toxic than proguanil when administered orally to mice infected with P. berghei. When administered orally to Aotus monkeys infected with multidrug-resistant P. falciparum, PS-15 was more active than either proguanil or WR99210[1].
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 55 mg/ml (127.57 mM)
關(guān)鍵字WR99210 | WR 99210
相關(guān)庫抗寄生蟲庫 | 經(jīng)典已知活性庫 | ReFRAME 相關(guān)化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | 抗感染化合物庫 | 人代謝物化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

Recommended supplier

Product name Price   Suppliers Update time
$1520.00/25mg
VIP3Y
TargetMol Chemicals Inc.
2024-10-23
$0.00/1kg
VIP5Y
Zison Pharmaceutical (Shandong) Co., Ltd.
2024-05-24
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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