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Postion:Product Catalog >WKYMVM 2TFA(187986-17-0(free base))
WKYMVM 2TFA(187986-17-0(free base))
  • WKYMVM 2TFA(187986-17-0(free base))

WKYMVM 2TFA(187986-17-0(free base)) NEW

Price $89 $342 $513
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-18

Product Details

Product Name: WKYMVM 2TFA(187986-17-0(free base)) Purity: 99.82%
Supply Ability: 10g Release date: 2024/11/18

Product Introduction

Bioactivity

NameWKYMVM 2TFA(187986-17-0(free base))
DescriptionWKYMVM 2TFA is a N-formyl peptide receptor (FPR1) agonist.
In vitroNeutrophils are activated by WKYMVM through FPRL1 and that FPRL2 is a chemotactic receptor transducing signals in myeloid cells[1].
In vivoUsing blood samples withdrawn from 28 AL patients and 31 healthy controls, found that, in the absence of exogenous WKYMVM, WKYMVM receptor and bactericidal activity did not differ between patients and controls.Addition of WKYMVM markedly increased the bactericidal activities of these cells in a dose-dependent manner.During induction chemotherapy, there were significant increases in bactericidal activity in the presence and absence of 1nM WKYMVM, with higher bactericidal activities at the time of complete remission than at the time of diagnosis or on day 15.During consolidation chemotherapy, WKYMVM had no effect on bactericidal activities.Patients showed significant increase in the concentrations of TNF alpha, IL-1b, IL-6 and IL-8, but significant decrease in the concentrations of IL-2, IL-4 and IL-12.TNF alpha, IL-1b and IL-6 showed significant negative correlations with bactericidal activities of patient neutrophils at time of diagnosis, and IL-4 showed a significant positive correlation with bactericidal activities,these findings indicate that WKYMVM enhances bactericidal activity in patients with AL[2].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 55 mg/mL (50.73 mM)
KeywordsWKYMVM 2TFA(187986170(free base)) | WKYMVM 2TFA(187986-17-0(free base)) | WKYMVM 2TFA(187986 17 0(free base))
Related Compound Libraries經(jīng)典已知活性庫(kù) | NO PAINS 化合物庫(kù) | 已知活性化合物庫(kù)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

Recommended supplier

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$137.00/1mg
VIP3Y
TargetMol Chemicals Inc.
2024-11-05
$0.00/1kg
VIP5Y
Zison Pharmaceutical (Shandong) Co., Ltd.
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VIP2Y
Wuhan Quanjinci New Material Co.,Ltd.
2023-10-24
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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