Product Details
Product Name:
WHI-P97 |
CAS No.:
211555-05-4 |
Purity:
99.93% |
Supply Ability:
10g |
Release date:
2024/11/07 |
Product Introduction
Bioactivity
名稱(chēng) | WHI-P97 |
描述 | WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. WHI-P97 did not directly inhibit the enzymatic activity of 5-LO, but prevented its translocation to the nuclear membrane without affecting the requisite calcium signal. |
存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 60 mg/mL (131.84 mM)
|
關(guān)鍵字 | WHI-P97 | Janus kinase | JAK | airway | Inhibitor | WHIP97 | eosinophil recruitment | inhibit | ovalbumin challenge | WHI P97 | ovalbumin-sensitized | WHI-P-97 |
相關(guān)產(chǎn)品 | Delgocitinib | Deucravacitinib | Fedratinib | RO8191 | Ruxolitinib | Tofacitinib Citrate | CEP-33779 | Ruxolitinib phosphate | JAK-IN-10 | Baricitinib | Tofacitinib | Ritlecitinib |
相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 激酶抑制劑庫(kù) | 血管生成庫(kù) | 抑制劑庫(kù) | 抗前列腺癌化合物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 臨床前化合物庫(kù) | 抗癌化合物庫(kù) | 抗肝癌化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
Product name |
Price |
|
Suppliers |
Update time |
|
$1980.00/50mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-23 |