Voreloxin hydrochloride NEW
| Price | $58 | $103 | $166 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: Voreloxin hydrochloride | CAS No.: 175519-16-1 |
| Purity: 99.85% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| 名稱 | Voreloxin hydrochloride |
| 描述 | Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity. |
| 細(xì)胞實驗 | Cell lines: P388 leukemia cells. Concentrations: about 10 μg/mL. Incubation Time: 72 hours. Method: Cells are seed in a 96-well microtiter plate (0.1 mL/well), preincubated for 24 h except for P388 cells, and incubated with various concentrations of a test compound in the 5% CO2 incubator at 37℃ for 72 h. Then, 0.02 mL MTT solution (5 mg/mL) is added in each well, and a further 4 h cells culturing is carried out. The medium is removed and 0.2 mL of DMSO is added in each well to dissolve the formed formazan. The absorbance is measured using Multiskan Bichromatic. |
| 動物實驗 | Animal Models: Mice implanted with P388 leukemia cells. Dosages: about 50 mg/kg. Administration: i.p. |
| 體外活性 | Voreloxin potentially inhibits the relaxation of topoisomerase II relaxation with IC50 of 3.2 μg /mL with no effect on topoisomerase II cleavage. Voreloxin has a cytotoxic activity against human tumor cell lines more potent than that of etoposide. [1] Voreloxin also has broad anti-proliferative activity in 15 cell lines, including 4 drug-resistant lines, with IC50 ranging from 0.04 to 1.155 μM. [2] |
| 體內(nèi)活性 | Voreloxin (50 mg/kg i.p.) shows potent antitumor activity in mice implanted with P388 leukemia cells. [1] Voreloxin (25 mg/kg i.v.) demonstrates strong tumor growth inhibition in 10 of 11 solid tumor (ovarian, breast, melanoma, gastric, colon, and lung) xenograft models, 2 hematologic tumor xenograft models, 3 multidrug resistant tumor models and 3 murine syngeneic tumor models (Colon 26, M5076 Ovarian Sarcoma, Lewis Lung carcinoma). [2] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 20 mg/ml (45.67 mM) |
| 關(guān)鍵字 | AG 7352 | Apoptosis | AG7352 | SNS-595 Hydrochloride | Inhibitor | SNS595 | inhibit | SNS 595 Hydrochloride | SNS595 Hydrochloride | AG-7352 | Voreloxin hydrochloride | SNS-595 | Voreloxin | Voreloxin Hydrochloride | SNS 595 | Topoisomerase |
| 相關(guān)產(chǎn)品 | Stavudine | 5-Fluorouracil | Acetylcysteine | Kaempferol | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin | Lidocaine hydrochloride |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 血液病分子庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌藥物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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