Vonoprazan Fumarate NEW
| Price | $40 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Vonoprazan Fumarate | CAS No.: 881681-01-2 |
| Purity: ≥98% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Vonoprazan Fumarate |
| Description | Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19 nM at pH 6.5. |
| In vitro | The inhibitory activity of Vonoprazan Fumurate was unaffected by ambient pH. The inhibition by Vonoprazan Fumurate was reversible and achieved in a K(+)-competitive manner, quite different from that by lansoprazole. Vonoprazan Fumurate exhibits porcine gastric H+ ,K+-ATPase activity in a concentration-dependent manner[4]. |
| In vivo | Vonoprazan Fumurate, at a dose of 4 mg/kg (as the free base) orally, completely inhibited basal and 2-deoxy-d-glucose-stimulated gastric acid secretion in rats, and its effect on both was stronger than that of lansoprazole. Vonoprazan Fumurate increased the pH of gastric perfusate to a higher value than did lansoprazole or SCH28080, and the effect of Vonoprazan Fumurate was sustained longer than that of lansoprazole or SCH28080[4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 4.61 mg/mL (10 mM), Sonication is recommended. |
| Keywords | peptic | potassium | secretion | reflux | competitive | proton | inhibitor | antisecretory | disease | gastroesophageal | inhibit | Vonoprazan | ulcer | GERD | blocker | acid | gastric | Vonoprazan Fumarate | pump | P-CAB | Proton Pump |
| Inhibitors Related | Ilaprazole | Omeprazole Sodium | Esomeprazole | Abscisic Acid | Esomeprazole Magnesium | Pantoprazole Sodium Hydrate | Lansoprazole | Zinc pyrithione | Esomeprazole Sodium | Pantoprazole |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/10g |
VIP3Y
|
HangZhou RunYan Pharma Technology Co.,LTD.
|
2024-09-21 | |
| $35.00/1kg |
Hebei Xinsheng New Material Technology Co., LTD.
|
2023-10-12 | ||
| $0.00/1g |
VIP2Y
|
shandong perfect biotechnology co.ltd
|
2023-08-03 | |
| $0.00/25kg |
PNP Biotech Co. Ltd
|
2022-10-17 | ||
| $0.00/1KG Ton |
VIP3Y
|
Zhuhai Hairuide Bioscience and Technology Co., Ltd
|
2022-10-09 | |
| $1.10/1g |
VIP4Y
|
Dideu Industries Group Limited
|
2021-08-02 | |
| $7.00/1KG |
VIP7Y
|
Career Henan Chemical Co
|
2019-09-01 | |
| $0.00/1kg |
Hebei Xinsheng New Material Technology Co., LTD.
|
2023-09-12 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY