Vinpocetine NEW
Price | Get Latest Price | ||
Package | 1kg | 10kg | 25kg |
Min. Order: | 1kg |
Supply Ability: | 2000 |
Update Time: | 2024-12-06 |
Product Details
Product Name: Vinpocetine | CAS No.: 42971-09-5 |
EC-No.: 256-028-0 | Min. Order: 1kg |
Purity: 99% | Supply Ability: 2000 |
Release date: 2024/12/06 |
Factory Supply Vinpocetine CAS:42971-09-5
Product Name:Vinpocetine
Synonyms:CAVINTON;ETHYL APOVINCAMIN-22-OATE;EBURNAMENINE;EBURNAMENINE-14-CARBOXYLIC ACID ETHYL ESTER;RGH-4405;3A,16A-APOVINCAMINIC ACID ETHYL ESTER;(3A,16A)-EBURNAMENINE-14-CARBOXYLIC ACID ETHYL ESTER;VINPOCETIN
CAS:42971-09-5
MF:C22H26N2O2
MW:350.46
EINECS: 256-028-0
Melting point:147-153 °C dec.
alpha :D20 +114° (c = 1 in pyridine)
Boiling point:484.44°C (rough estimate)
density :1.1260 (rough estimate)
refractive index:1.6500 (estimate)
storage temp.:Sealed in dry,2-8°C
solubility:DMSO: 5 mg/mL
Usage:Cerebrovascular drug. A alkaloid extracted from apocynaceae plant, Vincamine derivatives. Selectively inhibit vascular smooth muscle calcium dependency phosphodiesterase, and increase the content of cGMP, expanse cerebral vascular, which in turn increase cerebral blood flow, improve cerebral circulation, but has little effects on the cardiovascular and blood pressure. Effectively, good tolerance, less adverse reaction. Used for dizziness, headache, memory disorders, movement disorder, aphasia, hypertensive encephalopathy, etc.. Can also be used in brain blood circulation obstacle caused by mental or neurological symptoms.
Description
Vinpocetine (42971-09-5) is a phosphodiesterase PDE1 inhibitor (IC50=21 μM).1?Also blocks voltage-gated Na+?channels, IC50=44.2 μM (potency similar to phenytoin), a mechanism which may contribute to its neuroprotective and anticonvulsant activity.2?It reduces inflammatory IL-1β and TNF-α expression in rat hippocampus.3?Displays beneficial effects in a rat model of cerebral ischemia-reperfusion injury.4?Vinpocetine exerts neuroprotective effects by suppressing microglial inflammation.5
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