Vernakalant Hydrochloride NEW
| Price | $68 | $98 | $178 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: Vernakalant Hydrochloride | CAS No.: 748810-28-8 |
| Purity: 99.04% | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | Vernakalant Hydrochloride |
| 描述 | Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker. |
| 體外活性 | Block of Kv1.5 by Vernakalant Hydrochloride occurs after channel activation, as Vernakalant induces a rapid block of channel current upon depolarization with minimal resting or “tonic” block. The most significant effect is the reduction in potency at I502A, with an IC50 of 329±19 μM (n=4-10) compared to a control IC50 of 13.4±0.9 μM (n=5-23), reflecting a 25-fold potency decrease. Lesser reductions in potency, between 3- and 4-fold, were noted for V505A, I508A, T480A, and C500A. For wild-type and mutant Kv1.5 channels, IC50 for Vernakalant block are 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channels, Kv1.5 channelI508F, and Kv1.5 channelT479A, respectively [1]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (116.6 mM), Sonication is recommended. H2O : 45 mg/mL (116.6 mM), Sonication is recommended. |
| 關(guān)鍵字 | RSD-1235 Hydrochloride | RSD1235 Hydrochloride | Vernakalant Hydrochloride | RSD 1235 Hydrochloride |
| 相關(guān)產(chǎn)品 | Minoxidil sulfate | Phenytoin sodium | Lidocaine | Valproic Acid | Lidocaine hydrochloride | L-Aspartic aicd sodium | Mebeverine hydrochloride | Amitriptyline hydrochloride | Riluzole | Indapamide |
| 相關(guān)庫 | 疼痛相關(guān)化合物庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | EMA 上市藥物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 抗癌上市藥物庫 | 已知活性化合物庫 | 離子通道庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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