VER49009 NEW
| Price | $55 | $77 | $113 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: VER49009 | CAS No.: 940289-57-6 |
| Purity: 99.17% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | VER49009 |
| Description | VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM). |
| Cell Research | Antiproliferative effects are measured using the sulforhodamine B assay. HUVEC sensitivity is determined by an alkaline phosphatase method. (Only for Reference) |
| Kinase Assay | Fluorescence Polarization Assay: Binding of HSP90 inhibitors to human full-length recombinant HSP90β is determined by a competitive binding fluorescence polarization assay, using a fluorescent pyrazole resorcinol probe. |
| In vitro | In the human ovarian tumor model, intraperitoneal injection of VER-49009 (4 mg/kg) can induce the dissociation of HSP90 and ERBB2. In athymic mice, intravenous injection of VER-49009 (20 mg/kg) demonstrates efficacy. |
| In vivo | VER-49009 can induce the dissociation of HSP72 and HSP27 from their binding proteins, leading to cell cycle arrest. In recombinant yeast Hsp90 protein (IC50 = 167 nM), VER-49009 inhibits the endogenous ATPase activity. During the treatment of liver fibrosis, VER-49009 induces the accumulation of hepatic stellate cells (CFSC) in the G2 phase, inhibiting cell growth. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 71 mg/mL (183.1 mM) Ethanol : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | VER49009 | CCT 0129397 | CCT-0129397 |
| Inhibitors Related | Ethoxyquin | SNX0723 | Tamoxifen | DN401 | SNX2112 | Ganetespib | Teprenone | Elesclomol | Rifabutin | Palmitic acid | Paeoniflorin | Tamoxifen Citrate |
| Related Compound Libraries | Apoptosis Compound Library | Endoplasmic Reticulum Stress Compound Library | HIF-1 Signaling Pathway Compound Library | Anti-Breast Cancer Compound Library | CNS-Penetrant Compound Library | Oxidation-Reduction Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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