Urolithin C NEW
| Price | $48 | $80 | $146 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: Urolithin C | CAS No.: 165393-06-6 |
| Purity: 98.16% | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | Urolithin C |
| 描述 | Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway. |
| 體外活性 | Urolithin C is a glucose-dependent activator of insulin secretion acting by facilitating L-type Ca2+ channel opening and Ca2+ influx into pancreatic β-cells.Urolithin C enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation as shown by higher phosphorylation levels in INS-1 β-cells[2]. Urolithin C stimulates reactive oxygen species (ROS) formation[2]. |
| 體內(nèi)活性 | In male Wistar rat, the half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V1/F) is 0.831 L/kg and the steady-state volume of distribution (Vss/F) is 55.6 L/kg after the intraperitoneal administration of Urolithin C (10 mg/kg)[3]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (204.75 mM), Sonication is recommended. |
| 關鍵字 | insulin | Ca channels | Apoptosis | Polyphenols | ROS | mitochondria | anti-diabetic | gut-microbial | Reactive Oxygen Species | Inhibitor | Endogenous Metabolite | glucose-dependent | Urolithin C | metabolite | Calcium Channel | β-cells | ERK1/2 | Ca2+ channels | inhibit |
| 相關產(chǎn)品 | Sucrose | Tributyrin | Glycerol | Thymidine |
| 相關庫 | 經(jīng)典已知活性庫 | 激酶抑制劑庫 | 微生物天然產(chǎn)物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 腸道微生物代謝化合物庫 | 離子通道庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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