Urapidil Hydrochloride
Price | $30 |
Package | 1KG |
Min. Order: | 1KG |
Supply Ability: | 20tons |
Update Time: | 2023-08-16 |
Product Details
Product Name: Urapidil Hydrochloride | CAS No.: 64887-14-5 |
Min. Order: 1KG | Purity: >99% |
Supply Ability: 20tons | Release date: 2023/08/16 |
Product Details
Product Name: Urapidil hydrochloride
Synonyms: 6[[3-[4-(O-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYLURACIL HYDROCHLORIDE;6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE;6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE HYDROCHLORIDE;URAPIDIL HCL;URAPIDIL HYDROCHLORIDE;URAPIDIL HYDROCHLORIDE A1 ADRENOCEPTOR A NTAG;6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-dione hydrochloride;6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione hydrochloride
CAS: 64887-14-5
MF: C20H30ClN5O3
MW: 423.94
EINECS: 636-348-0
Product Categories: Adrenoceptor;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 64887-14-5.mol
Urapidil is an antagonist of α1-adrenergic receptors (α1-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It selectively binds to α1- over α2-ARs (IC50s = 0.74 and 42 μM, respectively) and to 5-HT1A over 5-HT1B and 5-HT2 receptors (IC50s = 0.4, 20.4, and >10 μM, respectively) in rat cortex. Urapidil inhibits cAMP accumulation induced by forskolin in calf hippocampus as a functional model for 5-HT1A receptors (EC50 = 390 nM). It is also a β1-AR antagonist that inhibits the positive chronotropic response induced by isoproterenol in isolated rat atria (pA2 = 6.05). Urapidil (1 μmol/kg, i.v.) lowers mean arterial pressure (MAP) in anesthetized cats, an effect that is reduced by central administration of the 5-HT1A receptor antagonist spiroxatrine.
Urapidil Hcl CAS 64887-14-5 of Chemical Properties
Melting point 156-1580C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility H2O: soluble
form solid
color white
Water Solubility Soluble to 50 mM in water
Function and Application of Urapidil Hcl CAS 64887-14-5
1. α1-Adrenergic antagonist; derivative of Uracil (U801000). Antihypertensive.
2. Antihypertensive;Serotonergic receptor agonist
3. a1-Adrenergic antagonist; derivative of Uracil. Antihypertensive
Packaging And Shipping
Company Profile
Weijer International Trade (Hebei) Co., Ltd. is an enterprise located in Shijiazhuang, the capital of Hebei Province, China. We manufacture intermediates for several API’s falling under a wide range of therapeutic categories and also manufacture high-value fine chemicals & Specialty chemicals. Our products are sold all over the world (Europe, South America, North America, Southeast Asia, and Africa), and are highly praised by customers. Our company has reasonable prices and safe and efficient transportation methods, and has a strict quality management system and high-quality after-sales service, to meet the product and purchasing needs of new and old customers. Weijier also supports product customization.
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FAQ
1. How will you deliver the goods?
We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, and China Air Post. For container products, we can do sea shipping. You also can choose your own shipping forwarder.
2. How to start orders or make payments?
Proforma invoice will be sent first after confirmation of the order, enclosed our bank information. Payment by T/T, Western Union, L/C, Moneygram, BTC, Escrow.
3. How to contact us?
You can choose your interested products and send inquiry to us. You can chat with us via Trademanager, WhatsApp, and Skype Online. You can send us an email and you will receive our response.
4. How to confirm Product Quality before placing orders?
You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
5. How long is the lead time?
We deliver goods within 3 days for small order and 7-10 days for bulk order.
6. Is there any discount?
Yes, for larger quantity, we always support with better price.
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Company Profile Introduction
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- Since: 2017-04-05
- Address: Room 1304, Gaozhu Building, No. 3 Commercial Building, No. 210, Zhonghua North Street, Xinhua Distri
+86-15551193592
bruce@weijier.cn