Product Details
| Product Name:
UNC7467 |
CAS No.:
2922283-43-8 |
| Purity:
99.64% |
Supply Ability:
10g |
| Release date:
2024/11/12 |
Product Introduction
Bioactivity
| 名稱 | UNC7467 |
| 描述 | UNC7467 is a potent IP6K inhibitor with IC50 values of 4.9 nM for IP6K2, 8.9 nM for IP6K1, and 1320 nM for IP6K6. It effectively reduces inositol pyrophosphate levels without significantly affecting other inositol phosphates and is applicable for obesity research [1]. |
| 體外活性 | UNC7467 (2.5 μM; 3 hours; HCT116 cells) reduces inositol pyrophosphate levels, decreasing 5-InsP7 by 81% and 5-InsP8 by 63% [1]. |
| 體內活性 | UNC7467, administered at a dosage of 5 mg/kg through intraperitoneal injection daily for 4 weeks, significantly ameliorated diet-induced obesity, insulin resistance, and hepatic steatosis in mice with diet-induced obesity (DIO). This compound also demonstrated considerable pharmacokinetic benefits in DIO mice, presenting a low clearance rate of 13.7 (mL/min)/kg and yielding substantial area under the curve (AUC) values of 6054 h ng/mL for intravenous (i.v.) and 2527 h ng/mL for intraperitoneal (i.p.) routes at a 5 mg/kg dose. Furthermore, it improved glycemic profiles, mitigated hepatic steatosis, and curbed weight gain without affecting the mice's food intake. These findings underscore UNC7467's potential as an efficacious agent for treating diet-induced obesity and related metabolic disorders. |
| 存儲條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 3.15 mg/mL (10 mM)
|
| 關鍵字 | UNC7467 | UNC 7467 | UNC-7467 |
| 相關庫 | 經(jīng)典已知活性庫 | 抗肥胖化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States