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Postion:Product Catalog >Biochemical Engineering>Inhibitors>protein tyrosine kinase>UNC2881
UNC2881
  • UNC2881

UNC2881 NEW

Price $39 $68 $122
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: UNC2881 CAS No.: 1493764-08-1
Purity: 99.74% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameUNC2881
DescriptionUNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.
In vitroIn mice, UNC2881 exhibits a high total clearance rate (94.5 ml/kg/min), with an oral bioavailability of 14%.
In vivoUNC2881 inhibits the activity of Mer kinase in 697 B-ALL cells (IC50: 22 nM) and suppresses collagen-stimulated platelet aggregation.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationH2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 85 mg/mL (183.4 mM)
Ethanol : 5 mg/mL (10.78 mM), Heating is recommended.
KeywordsMer | phosphorylation | inhibit | orally active | UNC-2881 | UNC2881 | Tyro3 | pathologic thrombosis | Axl | UNC 2881 | Inhibitor | platelet aggregation | TAM Receptor
Inhibitors RelatedUNC2025 | Cabozantinib | Gilteritinib | Bemcentinib | SGI-7079 | Dubermatinib | Sitravatinib | NCT-503 | Cabozantinib S-malate | AXL-IN-13 | G-749 | BMS 777607
Related Compound LibrariesTarget-Focused Phenotypic Screening Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Kinase Inhibitor Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Anti-COVID-19 Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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