Ulipristal acetate NEW
| Price | $45 | $61 | $126 |
| Package | 5mg | 10mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Ulipristal acetate | CAS No.: 126784-99-4 |
| Purity: 99.94% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Ulipristal acetate |
| Description | Ulipristal acetate (CDB-2914) is an orally bioavailable selective progesterone receptor modulator with anti-progesterone activity. It binds to the progesterone receptor (PR), inhibiting PR-mediated gene expression and interfering with progesterone activity in the reproductive system, potentially suppressing the growth of uterine leiomyomatosis. Additionally, ulipristal can be used as emergency contraception by inhibiting or delaying ovulation and affecting endometrial tissue. |
| In vitro | Ulipristal acetate blocks activin A modulation of fibronectin and vascular endothelial growth factor A (VEGF-A) mRNA expression in cultured myometrial and leiomyoma cells[2]. Ulipristal acetate decreases the DNA fragmentation at the 100-ng/mL dose and continuing up to the 10,000-ng/mL dose compared to those spermatozoa in the control group[3]. |
| In vivo | Ulipristal and CDB-4124 exhibit notable antiprogestational effects in vivo[1]. Ulipristal acetate has been shown to reduce the occurrence of fibroadenomas and adenocarcinomas in the mammary glands across all groups studied. At the highest administered dose in rats, ulipristal acetate exposure [AUC(0-24h)] is 67 times the human therapeutic exposure at 10 mg/day. Importantly, in mice, ulipristal acetate does not lead to an increase in tumor formation, even at exposures up to 313 times the therapeutic level. Adverse effects in mice are confined to weight changes in specific organs (liver, pituitary, thyroid/parathyroid glands, and epididymis) and minimal panlobular hepatocellular hypertrophy at a dose of 130 mg/kg/day[4]. Additionally, ulipristal acetate at doses of 1 mg/kg and 5 mg/kg causes a dose-dependent increase in endometrial thickening, observed by pathologists more frequently than in controls. There is also a minor decrease in secretory differentiation as the dose of ulipristal acetate increases, indicated by reduced sub- and supra-nuclear vacuolation[5]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (105.12 mM) |
| Keywords | NR3C3 | inhibit | CDB2914 | Ulipristal Acetate | Ulipristal acetate | anti-fertility | anti-glucocorticoid | CDB 2914 | Autophagy | Inhibitor | anti-progestational | contraception | leiomyoma | uterine | emergency | Progesterone Receptor |
| Inhibitors Related | Hydroxychloroquine | Guanidine hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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