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Postion:Product Catalog >TUG-891
TUG-891
  • TUG-891

TUG-891 NEW

Price $34 $47 $77
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: TUG-891 CAS No.: 1374516-07-0
Purity: 99.21% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameTUG-891
DescriptionTUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.
Kinase AssayInhibition of recombinant human Mps1 by BAY 1161909 or BAY 1217389 is assessed in TRFRET-based in vitro kinase assays via phosphorylation of a biotinylated peptide (Biotin-Ahx-PWDPDDADITEILG-NH2). Under standard assay conditions kinase and test compound are preincubated for 15 min before enzyme reaction is started by addition of substrate and ATP upon 10 μM[1].
In vitroTUG-891 exhibits analogous signaling characteristics to the long-chain fatty acid (LCFA) α-linolenic acid at the human Free Fatty Acid receptor 4 (FFA4), stimulating Ca2+ mobilization, recruiting β-arrestin-1 and β-arrestin-2, and promoting extracellular signal-regulated kinase phosphorylation. Moreover, TUG-891 activation of FFA4 leads to the receptor's swift phosphorylation and internalization[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 40 mg/mL (109.77 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
KeywordsInhibitor | inhibit | Free Fatty Acid Receptor | TUG-891 | FFAR
Inhibitors RelatedVincamine | Monomethyl fumarate | Questiomycin A | 3-Hydroxyoctanoic Acid | CRTh2 antagonist 2 | Fezagepras sodium | Benzyl nicotinate | 1-methoxycyclopropanecarboxylic acid | TUG-1375 | CAY10595 | Timapiprant | NF-56-EJ40
Related Compound LibrariesTarget-Focused Phenotypic Screening Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | NO PAINS Compound Library | Endocrinology-Hormone Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | GPCR Compound Library | Anti-Metabolism Disease Compound Library | Human Metabolite Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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