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Postion:Product Catalog >API>Specialty drugs>Ophthalmic drugs>Tropicamide
Tropicamide
  • Tropicamide

Tropicamide NEW

Price $48
Package 100mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Tropicamide CAS No.: 1508-75-4
Purity: 99.78% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameTropicamide
DescriptionTropicamide (Ro 1-7683) is a synthetic muscarinic antagonist with anticholinergic properties similar to atropine. Upon ocular administration, it binds to and blocks muscarinic receptors in the sphincter and ciliary muscles, inhibiting cholinergic responses and causing pupil dilation and ciliary muscle paralysis. Tropicamide is used as a diagnostic agent to induce short-duration mydriasis and cycloplegia.
In vitroAt a concentration of 0.5%, Nepafenac significantly inhibits (46%) the breakdown of the blood-retinal barrier, leading to a 65% reduction in retinal edema, and almost completely suppresses PGE2 synthesis (96%). Nepafenac's bioavailability in ocular tissue is notably higher. Its inhibitory action on COX-1 is weaker (IC50: 64.3 μM). In rabbits, Nepafenac inhibits prostaglandin synthesis within the retina/choroid (55%) and in the iris/ciliary body (85-95%). Compared to control mice, Nepafenac substantially reduces choroidal neovascularization and ischemia-induced retinal neovascularization and also slows the increase in ischemia-induced retinal VEGF mRNA expression. In ocular and metastatic animal models, Nepafenac delays the progression of malignant tumors and decreases the weight of choroidal melanoma. In retinal microvessels of diabetic rats with insulin deficiency, Nepafenac markedly suppresses retinal prostaglandin E (2), superoxide, cyclooxygenase-2, and leukostasis, but does not affect vascular endothelial growth factor and nitric oxide. In diabetic rats, the compound significantly inhibits the number of dUTP nick end labeling (TUNEL) positive capillary cells, pericytes, and acellular capillaries mediated by transferase.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 60 mg/mL (211.01 mM), Sonication is recommended.
Ethanol : 53 mg/mL (186.4 mM)
Keywordsdilation | acetylcholine | Inhibitor | muscarinic | inhibit | pupil | cycloplegia | Tropicamide | mAChR | mydriasis | Muscarinic acetylcholine receptor
Inhibitors RelatedAdiphenine hydrochloride | Nanofin | Arecoline hydrobromide | Forskolin | CLOZAPINE N-OXIDE | Pilocarpine nitrate | Ribavirin | Adenine | Choline chloride | Propoxur
Related Compound LibrariesAnti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Pediatric Drug Library | Membrane Protein-targeted Compound Library | Anti-Parkinson's Disease Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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