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Postion:Product Catalog >API>Synthetic Anti-infective Drugs>Antiviral drugs>Trifluridine
Trifluridine
  • Trifluridine

Trifluridine NEW

Price $30 $46 $65
Package 10mg 25mg 50mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Trifluridine CAS No.: 70-00-8
Purity: 99.82% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameTrifluridine
DescriptionTrifluridine (NSC-75520) is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral activity.
In vitroDifferences in substrate specificity at TK1 and DUT resulted in substantial Trifluridine (FTD) incorporation into DNA. Trifluridine-treated cells display nuclear morphology compared to 2'-deoxy-5-fluorouridine-treated cells.Trifluridine dose-dependently inhibits the proliferation of human colorectal cancer cells transplanted into nude mice and mouse bone marrow cells.Trifluridine dose-dependently inhibits colony-forming bone marrow cells.
In vivoDifferences in substrate specificity at TK1 and DUT resulted in substantial Trifluridine (FTD) incorporation into DNA. Trifluridine-treated cells display nuclear morphology compared to 2'-deoxy-5-fluorouridine-treated cells.Trifluridine dose-dependently inhibits the proliferation of human colorectal cancer cells transplanted into nude mice and mouse bone marrow cells.Trifluridine dose-dependently inhibits colony-forming bone marrow cells.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationH2O : 14.8 mg/mL (50 mM)
DMSO : 55 mg/mL (185.69 mM), Sonication is recommended.
KeywordsTFT | Thymidylate Synthase | Nucleoside Antimetabolite/Analog | Herpes simplex virus | inhibit | Inhibitor | Trifluridine | HSV | NSC529182 | NSC-529182 | NSC-75520 | Orthopoxvirus | NSC75520
Inhibitors RelatedStavudine | Rifampicin | 5-Fluorouracil | Guanidine hydrochloride | 2,4-D | Oxyresveratrol | Thymidine | Temozolomide | Folic acid
Related Compound LibrariesBioactive Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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