Trifluoromethanesulfonic anhydride is an organic compound with chemical formula (CF3SO2)2O, is the acid anhydride of the strong acid trifluoromethanesulfonic acid, is a strong electrophilic reagent, can be used to introduce trifluoromethanesulfonyl.

Appearance and properties: Properties: Contact with air smoke, hygroscopic, with pungent smell of liquid. Density 1.67; Boiling point 81-83℃ Use: chemical intermediates colorless clarified liquid

Density: 1.677 g/mL at 25 °C(lit.)

Boiling point: 81-83 °C(lit.)

Melting point: -80°C

Flash point: 81-83°C

Refractive index: n20/D 1.321(lit.)

water solubility: reacts violently with water

Storage condition: Refrigerator

Vapor density: 5.2 (vs air)

Vapor pressure: 8 mm Hg (20 °C)

Usage:

1. Widely used in the synthesis of trifluoroformates.

2. Synthesis of trifluoromethanesulfonate and trifluoromethanesulfonamide. Aldoxime dehydration to nitrile. Preparation of epoxides from hydroperoxide. A synthesis of cyclobutanone, allenes and acetylenes.

3.Tf2O is a very widely used reagent in organic synthesis. Since trifluoromethyl sulfonate (Triflates) is a very good leaving group, the reaction activity can be greatly enhanced after the organic substrate is converted into corresponding Triflates by Tf2O treatment, and it is easy to achieve the conversion to other organic compounds.