Trazodone hydrochloride NEW
| Price | Get Latest Price |
| Package | 25KG |
| Min. Order: | 1KG |
| Supply Ability: | 50000KG/month |
| Update Time: | 2023-08-26 |
Product Details
| Product Name: Trazodone hydrochloride | CAS No.: 25332-39-2 |
| EC-No.: 246-855-5 | Min. Order: 1KG |
| Purity: 99% | Supply Ability: 50000KG/month |
| Release date: 2023/08/26 |
| CAS: | 25332-39-2 |
| MF: | C19H23Cl2N5O |
| MW: | 408.32 |
| EINECS: | 246-855-5 |
| Product Categories: | ANAHIST;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;25332-39-2 |
| Mol File: | 25332-39-2.mol |
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| Trazodone hydrochloride Chemical Properties |
| Melting point | 223-226?C |
| Fp | 9℃ |
| storage temp. | 2-8°C |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 23.3 mg/mL |
| form | powder |
| color | off-white |
| PH | pH (10g/l, 25℃) : 3.9～4.5 |
| Water Solubility | Soluble at 25mg/ml in methanol. Also soluble in 0.1M HCl or DMSO. Insoluble in water /n |
| InChIKey | OHHDIOKRWWOXMT-UHFFFAOYSA-N |
| CAS DataBase Reference | 25332-39-2(CAS DataBase Reference) |
| Trazodone hydrochloride Usage And Synthesis |
| Description | Trazodone Hydrochloride belongs to the hydrochloride salt form of trazodone with antidepressant and sedative activities, which is primarily used in the treatment of major depression. It serves as a serotonin uptake inhibitor that is effective for patients suffering from major depressive disorders and other subsets of depressive disorders, which is especially helpful for geriatric patients with severe agitation and certain depressive disorders associated with insomnia and anxiety since it has proved that trazodone also has anti-anxiety (anxiolytic) and sleep-inducing (hypnotic) effects. Besides, it is often prescribed as a sedative that is used for the treatment of panic attacks, aggressive behavior, agoraphobia, and cocaine withdrawal in combination with other drugs. Trazodone Hydrochloride is an oral drug that functions by affecting the balance of chemicals (neurotransmitters) within the brain that nerves use to communicate with (stimulate) each other. |
| References | https://en.wikipedia.org/wiki/Trazodone http://www.medicinenet.com/trazodone/article.htm https://www.drugbank.ca/drugs/DB00656 http://bodyandhealth.canada.com/drug/getdrug/ratio-trazodone https://pubchem.ncbi.nlm.nih.gov/compound/62935#section=Top |
| Chemical Properties | White to Off-White Solid |
| Originator | Trittico,Angelini,Italy,1972 |
| Uses | A serotonin uptake inhibitor |
| Uses | antihistamine |
| Uses | Monoamine reuptake inhibitor; antidepressant. |
| Definition | ChEBI: A hydrochloride salt prepared from equimolar amounts of trazodone and hydrogen chloride. |
| Manufacturing Process | In an initial step, 2-chloropyridine is reacted with semicarbazide to give s_x0002_triazolo-[4,3-a]-pyridine-3-one. To a boiling solution of 6.7 grams s-triazolo-[4,3-a]-pyridine-3-one in 80 ml dioxane, there is added 2.4 grams 50% NaH. The mixture is refluxed during 1 hour under stirring, then 13.5 grams 1-(3-chloropropyl)-4-mchlorophenylpiperazine is added. The mixture is refluxed under stirring for 20 hours, cooled, diluted with an equal volume of ether, the sodium chloride filtered out, and ethereal HCl added. The solid which precipitates is filtered out and crystallized from 95% alcohol. Yield is 13.5 grams, MP 223°C. The following is an alternative method of preparation: 1 gram 2-(γ- chloropropyl)-s-triazolo-[4,3-a]-pyridine-3-one and 5 ml saturated ammonia alcoholic solution are heated for 5 hours in a closed tube at 100°C. The contents of the tube are cooled, the ammonium chloride filtered out and the solvent is removed. There remains a residue of 0.9 grams 2-(γ-aminopropyl)- s-triazolo-[4,3-a]-pyridine-3-one. This residue is dissolved in isopropyl alcohol and 1 gram N-bis-chloroethylaniline is added to it. The mixture is refluxed for 3 hours. The solvent is removed at a reduced pressure, the residue is treated with 50% potassium carbonate, and extracted with ether. By treating with ethereal hydrochloric acid, 2-N'-m-chlorophenylpiperazino-propyl-s-triazole[4,3-a]pyridine-3-one hydrochloride is precipitated; MP 223°C. |
| Therapeutic Function | Tranquilizer |
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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