Product introduce:

Common Name	Topiramate
CAS Number	97240-79-4	Molecular Weight	339.362
Density	1.3±0.1 g/cm3	Boiling Point	438.7±55.0 °C at 760 mmHg
Molecular Formula	C12H21NO8S	Melting Point	125oC
MSDS	ChineseUSA	Flash Point	219.1±31.5 °C
Symbol	GHS02, GHS06, GHS08	Signal Word	Danger

Use of Topiramate

Topiramate is an anticonvulsant that antagonizes GluR5 receptors and acts as a positive allosteric modulator of GABA receptor-mediated currents.Target: GluR5 receptor; GABA receptorTopiramate (Topamax) is a structurally novel broad-spectrum antiepileptic drug (AED) with established efficacy as monotherapy or adjunctive therapy in the treatment of adult and paediatric patients with generalised tonic-clonic seizures, partial seizures with or without generalised seizures, and seizures associated with Lennox-Gastaut syndrome [1]. topiramate has been believed to be a type of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actions have been proven to include use-dependent inhibition of voltage-dependent Na+ channels in neurons, potentiation of GABA (gamma-amino-butyric acid)-induced Cl- influx, and inhibitory effects on inward currents by antagonizing kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors [2].Topiramate (median average dosage 5.1 mg/kg/day) was also found to be useful as adjunctive therapy in the management of Lennox-Gastaut syndrome and significantly reduced the mean frequency of drop attacks by 14.8% compared with an increase of 5.1% with placebo. Further gains in seizure control were made in a nonblind extension of this trial where the mean topiramate dosage was 10 mg/kg/day. Nine of 11 patients in 1 pilot trial of children with otherwise intractable West syndrome, and 5 of 10 in another, achieved a > or =50% reduction in seizure rate with topiramate (target dosage up to 24 mg/kg/day) [3].Clinical indications: Epilepsy; Lennox Gastaut syndrome; Migraine; Seizure disorder Toxicity:abdominal pain; agitation; blurred vision; convulsions; depression; dizziness; double vision; drowsiness; impaired coordination; impaired mental activity; low blood pressure; reduced consciousness; severe diarrhea; sluggishness and speech problems.

I am Mandy,

Email: sales12@hbouhuang.com

Telephone/Wechat: 0086–15629005126

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Ouhuang Engineering Materials(Hubei)Co.,Ltd

Packing,StorageTransportation:
1. Packing: 25 kg/bag
2. Storage: Store in a dry and ventilated place, and pay attention to moisture and humidity. Long-term storage does not deteriorate, if there is caking, crushing or dissolution does not affect the use effect.
3. Transportation: This product is non-toxic and harmless, non-flammable and explosive dangerous goods. It can be transported by car, sea or train. Less carload, vehicle is not limited, agent consignment.

Transport:
1.Transit could be DHL,UPS,TNT,EMS,Fedex,and so on.
2.For mass orders, it will be delivered by air or sea.
3.Depending on your location, please allow 1-5 business days for your order to arrive.
4.For small order, please expect 3-7 days by UPS DHL EMS.
5.For mass order, please allow 5-8 days by Air, 15-30 days by Sea.
Company Profile:
  We are Ouhuang Engineering Materials (Hubei) Co., Ltd.Our company mainly produces and sells various Building materials materials and various production AIDS water-based environmentally friendly resins (water-based resin powder, water-based rosin resin, water-based terpene tree, etc.), various water-based environmentally friendly latex (water-based thickened emulsion, water-based air-butyl latex, water-based butyl latex, etc.) , and various environmentally friendly additives (defoamer, thickener, antioxidant, dispersant).High-end product quality and sincere sales service are our tenets.We are willing to provide you with professional services in the areas we are familiar with and look forward to your consultation.  
Our advantage:
1.Our company has a professional research team to develop building raw materials chemical products and mature technicians to create value
2.We can also meet the special customization needs of customers as well as various special packaging requirements.
3.We can also provide samples to our customers free of charge.
4.We provide commercial invoice, packing list, Bill of Lading, COA, Health Certificate and Certificate of Origin. If your market has any special requirements, please let us know.
5.Prompt delivery, as long as you confirm that the order is available in stock can be arranged within 24h.
6.Diversification of payment methods,Such as L/C, T/T, D/A, D/P, paypal, Western Union etc, and we cooperate with Sinosure many years.
FAQ:

Q: What's your MOQ ?

A: It depends on the product you buy.

Q: Is there a discount ?

A: Yes, for larger quantity, we always support with better price.

Q: How to confirm the Product Quality before placing orders ?

A: You can get free samples for some proucts, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.

Q: How to start orders or make payments ?

A: You can send our your Purchase order ( if your company has ), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.

Q: How do you treat quality complaint ?

A: First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.

Welcome inquiry!