Tianeptine sodium is a selective serotonin reuptake enhancer (SSRE) used to treat major depressive episodes. Tianetine sodium salt is a tricyclic compound with psychostimulant, anti-ulcer and anti-emetic effects. Antidepressants.

Pharmacological action:

Tianeptine sodium is a tricyclic antidepressant, and its antidepressant mechanism is different from traditional tricyclic antidepressants. It can increase the reuptake of 5-HT in the synaptic gap, and may improve the transmission of 5-HT neurons. No affinity for choline or adrenergic receptors. Antidepressant efficacy is similar to tricyclic, but the tolerance is better than tricyclic. In animal experiments, it can increase the spontaneous activity of hippocampal pyramidal cells and accelerate the recovery of their function after inhibition. It can increase the reabsorption of serotonin by neurons in the cerebral cortex and hippocampus. The absorption of tineptine sodium in the digestive tract is rapid and complete. Rapid distribution, PPB up to 94%. It is completely metabolized in the liver by β-oxidation and N-demethylation, clearance of terminal T1/2 is short, 2.5h, and a very small amount of the drug (8%) is excreted from the kidney, mainly its metabolites from the urine. Patients with renal insufficiency cleared T1/2 for 1h.