Chinese name: Prorelin

English name: TRH

CAS: 24305-27-9

Molecular formula: C16H22N6O4

Molecular weight: 362.38

Appearance: white dry lyophilized powder, hygroscopic. Specific rotation [α]25D-65.5°(1%, water). Dissolve in water.

Melting point: >143°C (dec.)

Than the rotation: - 50 (D / 25 ℃) (c = 1.5, H2O) to 65.5 (D) (c = 1.0, H2O)

Boiling point: 494°C (rough estimate)

Density: 1.1675 (rough estimate)

Refractive index: 1.6000 (estimate)

Storage condition: ?20°C

Solubility: H2O: 10 mg/mL, clear, colorless

Acidity coefficient (pKa) : 13.05±0.20(Predicted)

Form: powder

Color: White to off-white

PH value: pH (10g/l, 25℃) : 3.0 ~ 4.0

Merck: 13,9663

BRN: 770238

Stability: hygroscopicity

InChIKey: ITYONPBTNRIEBA-SRVKXCTJSA-N

use

In addition to the treatment of shock, prorelin has other uses, such as the treatment of hypothalamic hypothyroidism, central hyperthyroidism in endocrinology. It is used in psychiatry to treat depression and schizophrenia. Neurology is used to treat brain and spinal cord injuries, coma of all causes, amyotrophic lateral sclerosis, spinocerebellar degeneration, senile dementia, epilepsy, etc.