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Postion:Product Catalog >Thiourea, N-(4-methoxyphenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]-
Thiourea, N-(4-methoxyphenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]-
  • Thiourea, N-(4-methoxyphenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]-
  • Thiourea, N-(4-methoxyphenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]-
  • Thiourea, N-(4-methoxyphenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]-
  • Thiourea, N-(4-methoxyphenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]-
  • Thiourea, N-(4-methoxyphenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]-

Thiourea, N-(4-methoxyphenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]- NEW

Price $6
Package 1kg
Min. Order: 1kg
Supply Ability: 200t
Update Time: 2024-11-18

Product Details

Product Name: Thiourea, N-(4-methoxyphenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]- CAS No.: 2413974-52-2
EC-No.: 974-152-2 Min. Order: 1kg
Purity: 99+ Supply Ability: 200t
Release date: 2024/11/18
Common NameMT-802
CAS Number2231744-29-7Molecular Weight787.82
DensityN/ABoiling PointN/A
Molecular FormulaC41H41N9O8Melting PointN/A
MSDSN/AFlash PointN/A

Names

NameMT-802

 MT-802 Biological Activity

DescriptionMT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL)[1].
Related Catalog
Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
Signaling Pathways >> PROTAC >> PROTAC
Target

DC50: 1 nM (BTK)[1].

In VitroMT-802 degrades BTK with a DC50 of 9.1 nM with maximal degradation being observed by 250 nM[1].
References

[1]. Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575.

 Chemical & Physical Properties

Molecular FormulaC41H41N9O8
Molecular Weight787.82
Storage condition-20°C


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