TG003 NEW

Price	$43	$98	$162
Package	1mg	5mg	10mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-15

Product Details

Product Name: TG003	CAS No.: 719277-26-6
Supply Ability: 10g	Release date: 2024/11/15

Product Introduction

Bioactivity

名稱	TG003
描述	TG003 is a potent Clk1/Sty inhibitor that inhibits Clk1 and Clk4, inhibits cancer cell growth and induces apoptosis, and can be used in the study of Duchenne muscular dystrophy.
體外活性	The small drug TG003 increases endogenous expression of p53β and p53γ protein isoforms by modulation of TP53 intron 9 alternative splicing. [1] TG003 exhibits the most potent effect on Clk1/Sty and Clk4 (IC50, 15–20 nM) with lesser effect on Clk2 (IC50=200 nM). TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA in vitro by suppression of Clk-mediated phosphorylation. [2]
體內(nèi)活性	Intrathecal injection of either TG003 (1-100 pM) or IC261 (0.1-1 nM) dose-dependently reduces mechanical allodynia and thermal hyperalgesia induced by carrageenan or CFA. [3]
存儲條件	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 100 mg/mL(401.07 mM), Sonication is recommended.
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Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.