Tetrandrine NEW
| Price | $43 | $89 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: Tetrandrine | CAS No.: 518-34-3 |
| Purity: 99.72% | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | Tetrandrine |
| 描述 | Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Tetrandrine inhibits voltage-gated calcium channels (ICa) and Ca2+-activated potassium channels. |
| 體外活性 | METHODS: Leukemia cell lines K562, THP-1, U937, and HL60 were treated with Tetrandrine (1-3 μM) for 24-72 h, and cell numbers were measured. RESULTS: 2 μM and 3 μM Tetrandrine significantly inhibited cell proliferation. [1] METHODS: A panel of GFP-LC3-expressing tumor cell lines MCF-7, PLC-5, SK-Hep1, HeLa, and PC3 cells were treated with Tetrandrine (5 μM) for 16 h and GFP-LC3 spots were detected. RESULTS: Tetrandrine significantly induced GFP-LC3 spot formation with similar potency (5 μM) in all cell lines tested.Tetrandrine induced autophagy in multiple cell lines. [2] |
| 體內(nèi)活性 | METHODS: To detect anti-tumor activity in vivo, athymic nude mice bearing THP-1 xenografts were administered Tetrandrine (25-50 mg/kg, 0.5% methylcellulose) by gavage once daily for 13 days. RESULTS: Tetrandrine treatment reduced tumor growth. [1] |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 0.7 mg/mL (1.12 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 50 mg/mL (80.29 mM) |
| 關(guān)鍵字 | Ca channels | KcsA | Potassium Channel | NSC 77037 | Calcium Channel | NSC77037 | Ca2+ channels | inhibit | Tetrandrine | Inhibitor |
| 相關(guān)產(chǎn)品 | Minoxidil sulfate | Nisoldipine | Diltiazem hydrochloride | Levetiracetam | L-Ascorbic acid | Lanthanum(III) chloride heptahydrate | Halothane | Ethyl cinnamate | 1-Octanol | Indapamide |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 中藥單體化合物庫 | 膜蛋白靶向化合物庫 | 生物堿類天然產(chǎn)物庫 | 天然產(chǎn)物庫 | 藥物功能重定位化合物庫 | 抗癌上市藥物庫 | 離子通道庫 | 古代經(jīng)典名方目錄分子庫 | 藥食同源庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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