Teprenone NEW
| Price | $46 | $62 | $143 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: Teprenone | CAS No.: 6809-52-5 |
| Purity: 99.96% | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | Teprenone |
| 描述 | Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs). |
| 體外活性 | Teprenone, known as Geranylgeranylacetone, is an inducer of Heat Shock Proteins (HSPs) and, at a concentration of 1 μM, notably mitigates ethanol-induced exfoliation and lowers lactate dehydrogenase (LDH) release in gastric mucosal cells. This compound elevates the HSC70 level over time and rapidly boosts stress-inducible HSP90, HSP70, and HSP60 concentrations within 30-60 minutes, also activating heat shock factor 1. At dosages ranging from 0 to 20 μM, Teprenone marginally increases the viability of human umbilical vein endothelial cells (HUVEC) post-irradiation (IR), and while 10 μM of Teprenone does not affect HUVEC migration and invasion, it notably promotes HUVEC tube formation and wound healing, with or without IR exposure. Furthermore, at this concentration, Teprenone fosters angiogenesis by inducing VEGF and eNOS expression in HUVECs. |
| 體內(nèi)活性 | Teprenone (200 mg/kg, p.o.) upregulates HSP70 mRNA in rats, a process amplified by mucosal stress in Teprenone-pretreated versus vehicle-pretreated rats. It significantly reduces stress-induced ulcer formation after 2 and 4 hours in rats[1]. Teprenone also enhances HSP72 expression, mitigates RGC loss, optic nerve damage, and apoptosis, and boosts HSP72 levels in a rat glaucoma model[2]. Additionally, Teprenone protects against radiation-induced intestinal injury in mice. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 25 mg/mL (75.63 mM) |
| 關(guān)鍵字 | HSP | Teprenone | Heat shock proteins | inhibit | Inhibitor |
| 相關(guān)產(chǎn)品 | Tamoxifen | Palmitic acid | Paeoniflorin |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 藥物功能重定位化合物庫 | 抗癌上市藥物庫 | 已知活性化合物庫 | 抗癌活性化合物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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