Tefinostat NEW

Price	$97	$239	$355
Package	1mg	5mg	10mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-19

Product Details

Product Name: Tefinostat	CAS No.: 914382-60-8
Purity: 99.41%	Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

Name	Tefinostat
Description	Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor that is cleaved to the active acid CHR-2847 by intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat exhibits antitumor activity and can be used in the study of leukemia and advanced hematologic malignancies.
In vitro	Tefinostat (1-4 nM; AML cell lines) demonstrates efficacy in AML cell lines, including HL60 (M2 FAB type), MV411 (M4, FLT3-ITD), OCIAML3 (M4 NPM1mut), and THP1 (M5), with EC50 values of 2.3 μM, 57 nM, 110 nM, and 560 nM, respectively.
Storage	store at low temperature,keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 90 mg/mL (181.59 mM), Sonication is recommended.
Keywords	Tefinostat \| CHR2845 \| CHR 2845
Inhibitors Related	Valproic acid sodium salt \| Panobinostat \| Theophylline monohydrate \| Sodium 4-phenylbutyrate \| Vorinostat \| Acefylline \| Valproic Acid \| Curcumin \| Parthenolide \| 4-Phenylbutyric acid \| Theophylline \| Methyl L-histidinate dihydrochloride
Related Compound Libraries	Histone Modification Compound Library \| DNA Damage & Repair Compound Library \| Reprogramming Compound Library \| Bioactive Compound Library \| Epigenetics Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| Anti-Aging Compound Library \| Immunology/Inflammation Compound Library \| Bioactive Compounds Library Max \| Anti-Cancer Active Compound Library \| Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.