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Postion:Product Catalog >TCS-PIM-1-4a
TCS-PIM-1-4a
  • TCS-PIM-1-4a

TCS-PIM-1-4a NEW

Price $47 $70 $126
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-17

Product Details

Product Name: TCS-PIM-1-4a CAS No.: 327033-36-3
Purity: 99.89% Supply Ability: 10g
Release date: 2024/11/17

Product Introduction

Bioactivity

名稱TCS-PIM-1-4a
描述TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).
體外活性One hour inhibitor treatment (0.5 μM) of HEK-293T cultures at the end of a 4 hour 32PO4 incubation period results in nearly complete inhibition of the autophosphorylation of overexpressed Pim-1. Comparing to Inhibitor VI (Cat. No. 526524), Inhibitor V is less reactive towards DYRK1α (20% vs. 68% inhibition with respective inhibitor at 5 μM) and more potent in PC3 human prostate cancer cell killing (IC50 = 17 vs. 48 μM with respective inhibitor).
存儲條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 55 mg/mL (201.3 mM)
關(guān)鍵字arrest | Bak | Leukemic | 4E-BP1 | mTORC1 | TCSPIM14a | Pim kinases | TCS PIM 1 4a | Inhibitor | Pim | p27Kip1 | cell-cycle | inhibit | Apoptosis | TCS-PIM-1-4a | Bax
相關(guān)產(chǎn)品Stavudine | 5-Fluorouracil | Acetylcysteine | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin
相關(guān)庫細(xì)胞重編程化合物庫 | 經(jīng)典已知活性庫 | 激酶抑制劑庫 | JAK-STAT 化合物庫 | 抗前列腺癌化合物庫 | 抑制劑庫 | 已知活性化合物庫 | 臨床前化合物庫 | 抗癌化合物庫 | 抗癌活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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